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SML2146

SR-18292 Maleate

Name: SR-18292 Maleate
Brand: SIGMA

≥98% (HPLC), hepatic gluconeogenesis inhibitor, powder

Synonym(s):

SR-18292 Maleate, 1-[(1,1-Dimethylethyl)[(4-methylphenyl)methyl]amino]-3-(1H-indol-4-yloxy)-2-propanol maleate, SR 18292, SR 18292 maleate

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About This Item

Empirical Formula (Hill Notation):

C₂₃H₃₀N₂O₂ · C₄H₄O₄

CAS Number:

2095432-55-4

Molecular Weight:

482.57

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

SR-18292 Maleate, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC(C)(C)N(CC(O)COC1=CC=CC2=C1C=CN2)CC3=CC=C(C)C=C3.O=C(O)/C=C\C(O)=O

InChI key

CMTOYDGVFTZNSM-BTJKTKAUSA-N

Description

Application

SR-18292 Maleate has been used as a peroxisome proliferator-activated receptor γ coactivator 1 α (PGC1α) inhibitor to study the protective effects of pioglitazone on demyelinated axons.

Biochem/physiol Actions

SR-18292 is a potent and specific inhibitor of hepatic gluconeogenesis via increased acetylation of PGC-1α and suppression of gluconeogenic gene expression. SR-18292 reduces blood glucose and increases hepatic insulin sensitivity in mouse models of T2D.

inhibitor of hepatic gluconeogenesis via increased acetylation of PGC-1α; anti-diabetic

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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