SML2150
AZ6102
≥98% (HPLC)
Synonym(s):
rel-2-[4-[6-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]-4-methyl-3-pyridinyl]phenyl]-3,7-dihydro-7-methyl-4H-pyrrolo[2,3-d]pyrimidin-4-one
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About This Item
Empirical Formula (Hill Notation):
C25H28N6O
CAS Number:
Molecular Weight:
428.53
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
CN1C=CC2=C1N=C(C3=CC=C(C4=CN=C(N5C[C@H](C)N[C@H](C)C5)C=C4C)C=C3)NC2=O
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
AZ6102 is a potent and selective Tankyrase 1/2 (TAMKS1/2) inhibitor that has 100-fold selectivity against other PARP family enzymes. AZ6102 is moderately orally bioavailable in rat and mice.
bioavailable, potent and selective Tankyrase 1/2 (TAMKS1/2) inhibitor
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Jeffrey W Johannes et al.
ACS medicinal chemistry letters, 6(3), 254-259 (2015-03-31)
The canonical Wnt pathway plays an important role in embryonic development, adult tissue homeostasis, and cancer. Germline mutations of several Wnt pathway components, such as Axin, APC, and ß-catenin, can lead to oncogenesis. Inhibition of the poly(ADP-ribose) polymerase (PARP) catalytic
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