SML2153
TAM1 hydrochloride
≥98% (HPLC)
Synonym(s):
5-Hydroxy-4-[(4-methyl-1-piperidinyl)methyl]-2-phenyl-3-benzofurancarboxylic acid ethyl ester Hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C24H27NO4 · HCl
CAS Number:
Molecular Weight:
429.94
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
TAM1 is an inhibitor of the thioesterase activity of Mycobacterium tuberculosis polyketide synthase Pks13. TAM1 binds to Pks13 TE domain. TAM1 exhibit a potent bactericidal activity against Mycobacterium Tuberculosis H37Rv strain.
inhibitor of the thioesterase activity of Mycobacterium tuberculosis polyketide synthase Pks13.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Thomas R Ioerger et al.
PloS one, 8(9), e75245-e75245 (2013-10-03)
Identification of new drug targets is vital for the advancement of drug discovery against Mycobacterium tuberculosis, especially given the increase of resistance worldwide to first- and second-line drugs. Because traditional target-based screening has largely proven unsuccessful for antibiotic discovery, we
Anup Aggarwal et al.
Cell, 170(2), 249-259 (2017-07-04)
Widespread resistance to first-line TB drugs is a major problem that will likely only be resolved through the development of new drugs with novel mechanisms of action. We have used structure-guided methods to develop a lead molecule that targets the
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SML2153-25MG | 04061835303458 |
| SML2153-5MG | 04061835303465 |
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