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Merck
CN

SML2169

Diphenidol hydrochloride

≥98% (HPLC)

Synonym(s):

α,α-Diphenyl-1-piperidinebutanol hydrochloride, Diphenyl(3-(1-piperidyl)propyl)carbinol hydrochloride, 1,1-Diphenyl-4-piperidino-1-butanol, Difenidol

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About This Item

Empirical Formula (Hill Notation):
C21H27NO · HCl
CAS Number:
3254-89-5
Molecular Weight:
345.91
UNSPSC Code:
12352100
NACRES:
NA.77
EC Number:
221-850-0
MDL number:
MFCD00151479

Key Documents

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InChI key

AVZIYZHXZAYGJS-UHFFFAOYSA-N

InChI

1S/C21H27NO.ClH/c23-21(19-11-4-1-5-12-19,20-13-6-2-7-14-20)15-10-18-22-16-8-3-9-17-22;/h1-2,4-7,11-14,23H,3,8-10,15-18H2;1H

SMILES string

Cl.OC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

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Biochem/physiol Actions

Diphenidol is a non-selective muscarinic acetylcholine receptor antagonist. Diphenidol is an antiemetic agent used in the treatment of vomiting and vertigo.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000489772
0000489772
0000227863
0000227863
0000387938

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Yu-Wen Chen et al.
Neuroscience letters, 552, 62-65 (2013-08-07)
Diphenidol has been shown to block voltage-gated Na(+) channels, which are associated with specific types of pain. Here, we evaluated the effects of diphenidol on chronic constriction injury (CCI)-evoked allodynia and expression of tumor necrosis factor-α (TNF-α). A peripheral nerve
Lin Zhang et al.
Forensic science, medicine, and pathology, 11(4), 570-576 (2015-10-21)
Diphenidol hydrochloride (DPN), a nonphenothiazinic antiemetic agent used primarily in patients with Meniere disease and labyrinthopathies to treat vomiting and vertigo, is considered to be a relatively safe drug. Since it was first approved in the United States in 1967

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