SML2184
Kevetrin hydrochloride
≥98% (HPLC)
Synonym(s):
Kevetrin hydrochloride, 4-Isothioureidobutyronitrile hydrochloride, Carbamimidothioic acid 3-cyanopropyl ester hydrochloride, NSC 525990 HCl
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About This Item
Empirical Formula (Hill Notation):
C5H9N3S · HCl
CAS Number:
Molecular Weight:
179.67
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI
1S/C5H9N3S.ClH/c6-3-1-2-4-9-5(7)8;/h1-2,4H2,(H3,7,8);1H
SMILES string
NC(SCCCC#N)=N.Cl
InChI key
NCXJZJFDQMKRKM-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
−20°C
Biochem/physiol Actions
Kevetrin is an activator/stabilizer of wild type p53 tumor suppressor protein in human lung carcinoma and ovarian cancer cells that induces cell cycle arrest and apoptosis. Additionally Kevetrin down-regulates oncogenic mutant p53 in OVCAR-3 ovarian cancer cells. Kevetrin inhibits tumor growth in xenograft model of ovarian cancer.
wild type p53 stabilizer
wgk
WGK 3
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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