SML2187
RL5a
≥98% (HPLC)
Synonym(s):
N2-[2-(2-Furanyl)-4-quinolinyl]-N1,N1-dimethyl-1,2-ethanediamine
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About This Item
Empirical Formula (Hill Notation):
C17H19N3O
CAS Number:
Molecular Weight:
281.35
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Product Name
RL5a, ≥98% (HPLC)
SMILES string
N(CCNc1c2c(nc(c1)c3[o]ccc3)cccc2)(C)C
InChI
1S/C17H19N3O/c1-20(2)10-9-18-15-12-16(17-8-5-11-21-17)19-14-7-4-3-6-13(14)15/h3-8,11-12H,9-10H2,1-2H3,(H,18,19)
InChI key
CRGKLHXVNVZAPA-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to very dark brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
RL5a is a potent inhibitor of the replication licensing system in human cells. RL5a blocks the binding of the origin recognition complex (ORC) to origin DNA, which is required interaction for licensing. RL5a appears to act as noncompetitive inhibitor of ORC with respect to ATP.
potent inhibitor of the replication licensing system.
Storage Class
11 - Combustible Solids
wgk
WGK 3
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Nicola J Gardner et al.
Cell chemical biology, 24(8), 981-992 (2017-08-07)
In late mitosis and G
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