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Merck
CN

SML2243

Sigma-Aldrich

BTSA1

≥98% (HPLC)

Synonym(s):

3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(2-thiazolyl)hydrazone]

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About This Item

Empirical Formula (Hill Notation):
C21H14N6OS2
CAS Number:
314761-14-3
Molecular Weight:
430.51
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

color

red to dark red-brown

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

O=C1N(C2=NC(C3=CC=CC=C3)=CS2)N=C(C4=CC=CC=C4)/C1=N\NC5=NC=CS5

InChI key

KYVZVVOQWWCVPP-HKOYGPOVSA-N

Biochem/physiol Actions

BTSA1 is orally available, highly specific and potent BAX activator that binds to N-terminal activation site of Bax and induces conformational changes. BTSA1 potently induces apoptosis in leukemia cell lines and patient samples while sparing healthy cells.
orally available, highly specific and potent BAX activator that binds to N-terminal activation site of Bax

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000047900
0000048238
0000040521

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Denis E Reyna et al.
Cancer cell, 32(4), 490-505 (2017-10-11)
The BCL-2 family protein BAX is a central mediator of apoptosis. Overexpression of anti-apoptotic BCL-2 proteins contributes to tumor development and resistance to therapy by suppressing BAX and its activators. We report the discovery of BTSA1, a pharmacologically optimized BAX

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