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SML2244

AC1903

≥98% (HPLC)

Synonym(s):

N-(2-Furanylmethyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine

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About This Item

Empirical Formula (Hill Notation):
C19H17N3O
CAS Number:
831234-13-0
Molecular Weight:
303.36
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD06609959
Assay:
≥98% (HPLC)
Form:
powder
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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

C12=CC=CC=C1N=C(NCC3=CC=CO3)N2CC4=CC=CC=C4

InChI

1S/C19H17N3O/c1-2-7-15(8-3-1)14-22-18-11-5-4-10-17(18)21-19(22)20-13-16-9-6-12-23-16/h1-12H,13-14H2,(H,20,21)

InChI key

OECUWHDVQIITIS-UHFFFAOYSA-N

Application

AC1903 has been used as a drug candidate in a high-throughput agar colony formation assay to identify its therapeutic efficiency against medulloblastoma.

Biochem/physiol Actions

Chronic administration of AC1903 averts the loss of podocytes in a transgenic rat model of focal segmental glomerulosclerosis (FSGS).
AC1903 is a specific inhibitor of TRPC5, the transient receptor potential canonical channel 5, a Ca2+ permeable nonselective cation channel highly expressed in brain and kidney. AC1903 did not inhibit TRPC4 or TRPC6 currents and showed no off-target effects in kinase profiling assays. It specifically blocked TRPC5 channel activity in glomeruli of proteinuric rats, suppressed severe proteinuria, showing a therapeutic benefit in a rat model of hypertensive proteinuric kidney disease.
Specific inhibitor of TRPC5

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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