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Merck
CN

SML2248

SK-216

≥98% (HPLC)

Synonym(s):

2-[5-[[6-[5-(1,1-Dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]-propanedioic acid sodium salt, SK 216, [5-[[6-[5-(1,1-dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]-propanedioic acid disodium salt

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About This Item

Empirical Formula (Hill Notation):
C29H29NNa2O6
CAS Number:
654080-03-2
Molecular Weight:
533.52
UNSPSC Code:
12352200
NACRES:
NA.21

Key Documents

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InChI

1S/C29H31NO6.2Na/c1-29(2,3)21-11-13-25-24(17-21)30-26(36-25)20-9-8-19-16-22(12-10-18(19)15-20)35-14-6-4-5-7-23(27(31)32)28(33)34;;/h8-13,15-17,23H,4-7,14H2,1-3H3,(H,31,32)(H,33,34);;/q;2*+1/p-2

InChI key

YYTGMMYYLGKWIK-UHFFFAOYSA-L

SMILES string

CC(C)(C)C(C=C1)=CC2=C1OC(C3=CC=C4C(C=CC(OCCCCCC(C([O-])=O)C([O-])=O)=C4)=C3)=N2.[2Na+]

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 0.5 mg/mL, clear (warmed)

storage temp.

room temp

Related Categories

Biochem/physiol Actions

SK-216 is an orally active potent and selective inhibitor of Plasminogen activator inhibitor-1 (PAI-1) that inhibits tumor progression and angiogenesis. SK-216 inhibits migration and tube formation of cultured human umbilical vein endothelial cells induced by various angiogenic factors. SK-116 prevents a formation of gastro-intestinal polyps in Min mice.
orally active potent and selective inhibitor of Plasminogen activator inhibitor-1 (PAI-1)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000053537
0000053539
0000040342

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