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Merck
CN

SML2256

D3-βArr

≥98% (HPLC)

Synonym(s):

N-(1-Phenylethyl)-2-(1-piperazinyl)-4-quinazolinamine, N-(1-Phenylethyl)-2-(piperazin-1-yl)quinazolin-4-amine

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About This Item

Empirical Formula (Hill Notation):
C20H23N5
CAS Number:
662164-09-2
Molecular Weight:
333.43
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD04077665
Assay:
≥98% (HPLC)
Form:
powder

Key Documents

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Product Name

D3-βArr, ≥98% (HPLC)

InChI

1S/C20H23N5/c1-15(16-7-3-2-4-8-16)22-19-17-9-5-6-10-18(17)23-20(24-19)25-13-11-21-12-14-25/h2-10,15,21H,11-14H2,1H3,(H,22,23,24)

InChI key

LOGWGZNWEWFTJV-UHFFFAOYSA-N

SMILES string

CC(C1=CC=CC=C1)NC2=NC(N3CCNCC3)=NC4=CC=CC=C42

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

positive allosteric modulator of TSHR (thyrotropin receptor) for β-Arr 1-mediated signaling
D3-βArr is a positive allosteric modulator of TSHR (thyrotropin receptor) for β-Arr 1-mediated signaling that initiates translocation of β-Arr 1 by direct TSHR activation, while showing no agonistic effect on cAMP production. D3-βarr is a positive allosteric modulator for TSH-enhanced osteoblast differentiation.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000043266
0000043267
0000035253

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Susanne Neumann et al.
The Journal of pharmacology and experimental therapeutics, 364(1), 38-45 (2017-11-02)
Recently, we showed that TSH-enhanced differentiation of a human preosteoblast-like cell model involved a β-arrestin 1 (β-Arr 1)-mediated pathway. To study this pathway in more detail, we sought to discover a small molecule ligand that was functionally selective toward human

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