SML2264
Col003
≥98% (HPLC)
Synonym(s):
2-Hydroxy-3-nitro-5-(phenylmethyl)benzaldehyde
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About This Item
Empirical Formula (Hill Notation):
C14H11NO4
CAS Number:
Molecular Weight:
257.24
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Product Name
Col003, ≥98% (HPLC)
InChI
1S/C14H11NO4/c16-9-12-7-11(6-10-4-2-1-3-5-10)8-13(14(12)17)15(18)19/h1-5,7-9,17H,6H2
InChI key
RKJXVCLOGNLZOI-UHFFFAOYSA-N
SMILES string
OC1=C(C=C(C=C1C=O)CC2=CC=CC=C2)[N+]([O-])=O
assay
≥98% (HPLC)
form
powder
color
yellow to orange
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
Col003 is a cell penetrant, selective and potent inhibitor of the interaction of Hsp47 with collagen. It binds to the collagen binding site on Hsp47. Col003 inhibits a collagen secretion by destabilization the collagen triple helix. Additionally Col003 weakly inhibits interaction of collagen with prolyl 4-hydroxylase (P4H).
cell penetrant, selective and potent inhibitor of the interaction of Hsp47 with collagen
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Shinya Ito et al.
The Journal of biological chemistry, 292(49), 20076-20085 (2017-10-14)
Fibrosis can disrupt tissue structure and integrity and impair organ function. Fibrosis is characterized by abnormal collagen accumulation in the extracellular matrix. Pharmacological inhibition of collagen secretion therefore represents a promising strategy for the management of fibrotic disorders, such as
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