Oxaphenamide

Name: Oxaphenamide
Brand: SIGMA

≥98% (HPLC)

Synonym(s):

2-Hydroxy-N-(4-hydroxyphenyl)benzamide, 4′-Hydroxysalicylanilide, Osalmide, Oxaphenamide, p-hydroxyphenylsalicylamide

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₁NO₃

CAS Number:

526-18-1

Molecular Weight:

229.23

UNSPSC Code:

12352200

NACRES:

NA.77

EC Number:

208-385-9

MDL number:

MFCD00020026

Assay:

≥98% (HPLC)

Form:

powder

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Properties

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N(c2ccc(cc2)O)C(=O)c1c(cccc1)O

InChI

1S/C13H11NO3/c15-10-7-5-9(6-8-10)14-13(17)11-3-1-2-4-12(11)16/h1-8,15-16H,(H,14,17)

InChI key

LGCMKPRGGJRYGM-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Osalmid is a potent inhibitor of ribonucleotide reductase small subunit M2 (RRM2) that potently inhibits HBV DNA and cccDNA synthesis in HepG2.2.15 cells. Osalmid inhibits RR (ribonucleotide reductase) activity in vivo, and exhibits synergistic effect with lamivudine on inactivation mutant HBV strain. Osalmid is a biliation activator (choleretic agent), but a mechanism of this activity remains unknown.

potent inhibitor of ribonucleotide reductase small subunit M2 (RRM2) that potently inhibits HBV DNA and cccDNA synthesis; choleretic agent