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Merck
CN

SML2350

Ferroquine

≥98% (HPLC)

Synonym(s):

1-[[(7-Chloro-4-quinolinyl)amino]methyl]-2-[(dimethylamino)methyl]-ferrocene, 7-Chloro-4-(((2-((dimethylamino)methyl)ferrocenyl)methyl)amino)quinoline, Ferrochloroquine, SSR 97193

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About This Item

Empirical Formula (Hill Notation):
C23H24ClFeN3
CAS Number:
185055-67-8
Molecular Weight:
433.75
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

Key Documents

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Product Name

Ferroquine, ≥98% (HPLC)

SMILES string

CN(C)C[C]1[C]C[C][C]1CNC2=C(C=CC(Cl)=C3)C3=NC=C2.[C]4[C][C][C]C4.[Fe]

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

yellow to brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Antimalarial effective against chloroquine-resistant Plasmodium falciparum
Ferroquine (SSR 97193) is an antimalarial chloroquine analog effective against chloroquine-resistant Plasmodium falciparum. Ferroquine is thought to act by producing oxidative stress and by inhibiting the formation of hemozoin, produced by Malaria parasites as a disposal product of heme, which would otherwise be toxic to the Plasmodium cells.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000048111
0000048112
0000040813

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Jana Held et al.
The Lancet. Infectious diseases, 15(12), 1409-1419 (2015-09-08)
Artemisinin-based combination therapies (ACTs) are the recommended first-line treatment for uncomplicated Plasmodium falciparum malaria. Ferroquine is a new combination partner for fast-acting ACTs such as artesunate. We aimed to assess different doses of ferroquine in combination with artesunate against uncomplicated
Waseem A Wani et al.
European journal of medicinal chemistry, 101, 534-551 (2015-07-21)
Malaria has been teasing human populations from a long time. Presently, several classes of antimalarial drugs are available in market, but the issues of toxicity, lower efficacy and the resistance by malarial parasites have decreased their overall therapeutic indices. Thus
Artem Kondratskyi et al.
Scientific reports, 7(1), 15896-15896 (2017-11-23)
Despite the tremendous progress in medicine, cancer remains one of the most serious global health problems awaiting new effective therapies. Here we present ferroquine (FQ), the next generation antimalarial drug, as a promising candidate for repositioning as cancer therapeutics. We

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