SML2386
Cycloguanil hydrochloride
≥95% (HPLC)
别名:
1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diamine hydrochloride
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关于此项目
经验公式（希尔记法）:
C11H14ClN5 · HCl
化学文摘社编号:
分子量:
288.18
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.21
Assay:
≥95% (HPLC)
Form:
powder
Storage condition:
desiccated
assay
≥95% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
Clc1ccc(cc1)N2C(NC(=N)NC2=N)(C)C.Cl
InChI
1S/C11H14ClN5.ClH/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8;/h3-6H,1-2H3,(H4,13,14,15,16);1H
InChI key
MOUAPRKJJUXEIE-UHFFFAOYSA-N
Application
Cycloguanil hydrochloride is suitable for use as a positive control in screening Plasmodium falciparum strains in microdilution radioisotope antiplasmodial bioassay. It may also be used as internal standard in high performance liquid chromatography for the quantification of urine and plasma samples.
Biochem/physiol Actions
Cycloguanil is it a potential antimalarial drug. It is hydrophilic in nature. Cycloguanil acts as a substrate for the enzyme organic cation transporter 1 (OCT1).
Cycloguanil, a metabolite of proguanil, is a potent dihydrofolate reductase inhibitor.
Dihydrofolate reductase inhibitor, metabolite of proguanil
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
4.1B - Flammable solid hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable