SML2390
JNS 1-40
≥95% (HPLC)
Synonym(s):
N-benzyl-2-chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetamide
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About This Item
Empirical Formula (Hill Notation):
C17H16ClNO3
CAS Number:
Molecular Weight:
317.77
UNSPSC Code:
12352200
NACRES:
NA.21
Assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(CCl)N(CC1=CC=CC=C1)C2=CC3=C(OCCO3)C=C2
InChI
1S/C17H16ClNO3/c18-11-17(20)19(12-13-4-2-1-3-5-13)14-6-7-15-16(10-14)22-9-8-21-15/h1-7,10H,8-9,11-12H2
InChI key
POYZNHCCXQEULA-UHFFFAOYSA-N
Biochem/physiol Actions
JNS 1-40 is a potent and selective cysteine-reactive covalent ligand of regulatory subunit PPP2R1A of the tumor-suppressor protein phosphatase 2A (PP2A) that activate PP2A in vitro and in vivo. JNS 1-40 targets C377 of PPP2R1A and inhibits breast cancer proliferation, and in vivo tumor growth.
cysteine-reactive covalent ligand of regulatory subunit PPP2R1A of the PP2A that activate PP2A
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Elizabeth A Grossman et al.
Cell chemical biology, 24(11), 1368-1376 (2017-09-19)
Many natural products that show therapeutic activities are often difficult to synthesize or isolate and have unknown targets, hindering their development as drugs. Identifying druggable hotspots targeted by covalently acting anti-cancer natural products can enable pharmacological interrogation of these sites
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