SML2390
JNS 1-40
≥95% (HPLC)
Synonym(s):
N-benzyl-2-chloro-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetamide
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About This Item
Empirical Formula (Hill Notation):
C17H16ClNO3
CAS Number:
Molecular Weight:
317.77
UNSPSC Code:
12352200
NACRES:
NA.21
Assay:
≥95% (HPLC)
Form:
powder
assay
≥95% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(CCl)N(CC1=CC=CC=C1)C2=CC3=C(OCCO3)C=C2
InChI
1S/C17H16ClNO3/c18-11-17(20)19(12-13-4-2-1-3-5-13)14-6-7-15-16(10-14)22-9-8-21-15/h1-7,10H,8-9,11-12H2
InChI key
POYZNHCCXQEULA-UHFFFAOYSA-N
Biochem/physiol Actions
JNS 1-40 is a potent and selective cysteine-reactive covalent ligand of regulatory subunit PPP2R1A of the tumor-suppressor protein phosphatase 2A (PP2A) that activate PP2A in vitro and in vivo. JNS 1-40 targets C377 of PPP2R1A and inhibits breast cancer proliferation, and in vivo tumor growth.
cysteine-reactive covalent ligand of regulatory subunit PPP2R1A of the PP2A that activate PP2A
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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