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Merck
CN

SML2409

NITD008

≥98% (HPLC), falviviruses inhibitor, powder

Synonym(s):

7-(2-C-Ethynyl-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, 7-Deaza-2′-C-acetylene-adenosine, NITD 008

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About This Item

Empirical Formula (Hill Notation):
C13H14N4O4
CAS Number:
1044589-82-3
Molecular Weight:
290.27
NACRES:
NA.77
UNSPSC Code:
12352200
MDL number:
MFCD27952796

Key Documents

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Product Name

NITD008, ≥98% (HPLC)

InChI

1S/C13H14N4O4/c1-2-13(20)9(19)8(5-18)21-12(13)17-4-3-7-10(14)15-6-16-11(7)17/h1,3-4,6,8-9,12,18-20H,5H2,(H2,14,15,16)/t8-,9-,12-,13-/m1/s1

SMILES string

NC1=C2C=CN(C2=NC=N1)[C@@H]3O[C@@H]([C@H]([C@](C#C)3O)O)CO

InChI key

NKRAIOQPSBRMOV-NRMKKVEVSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

−20°C

Related Categories

Biochem/physiol Actions

NITD008 is a selective inhibitor of flaviviruses including dengue virus (EC50 = 0.64 μM), hepatitis C virus and Zika virus, and has also been shown to inhibit tick-borne flaviviruses in vitro. NITD008 has been reported to inhibit RNA-dependent RNA polymerase (RdRp), an essential protein of RNA viruses.
Selective inhibitor of flaviviruses including dengue virus, hepatitis C virus, and Zika virus

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000475311
0000475310
0000363289
0000310664
0000310665

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Amjad Ali et al.
Asian Pacific journal of tropical medicine, 10(4), 321-331 (2017-05-30)
Zika virus (ZIKV) is rapidly spreading across the America and its devastating outcomes for pregnant women and infants have driven this previously ignored pathogen into the limelight. Clinical manifestations are fever, joint pain or rash and conjunctivitis. Emergence of ZIKV
Michael K Lo et al.
Antiviral research, 130, 46-49 (2016-03-27)
There are currently no antiviral therapies available for the tick-borne flaviviruses associated with hemorrhagic fevers: Kyasanur Forest disease virus (KFDV), both classical and the Alkhurma hemorrhagic fever virus (AHFV) subtype, and Omsk hemorrhagic fever virus (OHFV). In this brief study
Zheng Yin et al.
Proceedings of the National Academy of Sciences of the United States of America, 106(48), 20435-20439 (2009-11-18)
Dengue virus (DENV), a mosquito-borne flavivirus, is a major public health threat. The virus poses risk to 2.5 billion people worldwide and causes 50 to 100 million human infections each year. Neither a vaccine nor an antiviral therapy is currently

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