SML2437
H-151
≥98% (HPLC), STING protein antagonist, powder
Synonym(s):
1-(4-Ethylphenyl)-3-(1H-indol-3-yl) urea
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About This Item
Empirical Formula (Hill Notation):
C17H17N3O
CAS Number:
Molecular Weight:
279.34
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
H-151, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
[nH]1c2c(c(c1)NC(=O)Nc3ccc(cc3)CC)cccc2
InChI
1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21)
InChI key
UJZDIKVQFMCLBE-UHFFFAOYSA-N
Biochem/physiol Actions
Antagonist of the stimulator of interferon genes (STING) protein
H-151 is an irreversible antagonist of the stimulator of interferon genes (STING) protein, a central signalling component of the cytosolic DNA sensing pathway. Although STING is a vital component of the innate immune pathways, it has also been shown to have a pathogenic role in some inflammatory diseases. H-151 is a potent and selective STING antagonist with inhibitory activity both in human cells and in vivo in mice. Given as a pretreatment, H-151 was shown to attenuate pathological features of autoinflammatory disease in mouse models, reducing systemic cytokine responses in mice treated with the STING agonist 10-carboxymethyl-9-acridanone (CMA)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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