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Merck
CN

SML2455

Sigma-Aldrich

MEPB

≥98% (HPLC)

Synonym(s):

2-((2-phenoxyethyl)thio)-1-(2-(p-tolyloxy)ethyl)-1H-benzo[d]imidazole

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About This Item

Empirical Formula (Hill Notation):
C24H24N2O2S
CAS Number:
331948-99-3
Molecular Weight:
404.52
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

CC(C=C1)=CC=C1OCCN2C(SCCOC3=CC=CC=C3)=NC4=CC=CC=C42

InChI

1S/C24H24N2O2S/c1-19-11-13-21(14-12-19)27-16-15-26-23-10-6-5-9-22(23)25-24(26)29-18-17-28-20-7-3-2-4-8-20/h2-14H,15-18H2,1H3

InChI key

PNCBJXVNIRRHJP-UHFFFAOYSA-N

Biochem/physiol Actions

MEPB is a modulator of the activation function-2 (AF-2) of the androgen receptor (AR), increasing AR co-repressor binding. MEPB specifically binds the BF3 pocket of the androgen receptor where it modulates binding of co-regulators to the AF2 domain. MEPB was found to rescue degeneration in a mouse model of spinal bulbar muscular atrophy, a motor neuron disease caused by toxic gain of function of the androgen receptor.
Modulator of the activation function-2 (AF-2) of the androgen receptor (AR)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000110006
0000064976
0000064977
0000059912

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