SML2464
KRN2
≥98% (HPLC)
Synonym(s):
KRN2, 13-[(2-Fluorophenyl)methyl]-5,6-dihydro-9,10-dimethoxy-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride
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About This Item
Empirical Formula (Hill Notation):
C27H23FClNO4
CAS Number:
Molecular Weight:
479.93
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
faint yellow to dark orange
solubility
H2O: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
FC(C=CC=C1)=C1CC2=C([N+](CC3)=CC4=C2C=CC(OC)=C4OC)C5=C3C=C(OCO6)C6=C5.[Cl-]
InChI key
RPHFGOXVJGNJJH-UHFFFAOYSA-M
Biochem/physiol Actions
KRN2 or 13-(2-fluorobenzyl)-berberine is a berberine derivative that effectively blocks the invasiveness of fibroblast-like synoviocytes (FLS). It is stable and orally bioavailable. It suppresses the production of proinflammatory cytokines to ameliorate arthritis severity.
KRN2 is a specific and potent inhibitor of nuclear factor of activated T cells 5 (NFAT5) that inhibits formation of NF-κB p65-DNA complexes. KRN2 suppresses migration of Fibroblast-like synoviocytes stimulated with TGF-β. KRN2 ameliorates experimental arthritis in mice.
specific and potent inhibitor of nuclear factor of activated T cells 5 (NFAT5) that inhibits formation of NF-κB p65-DNA complexes
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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