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Merck
CN

SML2473

Pitavastatin calcium

≥98% (HPLC), HMG CoA reductase inhibitor, powder

Synonym(s):

(+)monocalcium bis{(3R, 5S, 6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5dihydroxy-6-heptenoate}, (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid calcium salt

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About This Item

Empirical Formula (Hill Notation):
C25H23FNO4 · 0.5Ca
CAS Number:
147526-32-7
Molecular Weight:
440.49
UNSPSC Code:
51111800
NACRES:
NA.77

Key Documents

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Product Name

Pitavastatin calcium, ≥98% (HPLC)

SMILES string

[Ca+2].Fc5ccc(cc5)c6c7c(nc(c6\C=C\[C@@H](O)C[C@@H](O)CC(=O)[O-])C8CC8)cccc7.Fc1ccc(cc1)c2c3c(nc(c2\C=C\[C@@H](O)C[C@@H](O)CC(=O)[O-])C4CC4)cccc3

InChI

1S/2C25H24FNO4.Ca/c2*26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31;/h2*1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31);/q;;+2/p-2/b2*12-11+;/t2*18-,19-;/m11./s1

InChI key

RHGYHLPFVJEAOC-FFNUKLMVSA-L

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +19 to +24°, c = 1 in acetonitrile: water (1:1)

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

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Related Categories

Biochem/physiol Actions

HMG CoA reductase inhibitor
Pitavastatin calcium is a water-soluble inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Pitavastatin calcium is antilipidemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361f

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000480295
0000497494
0000497493
0000480295
0000497493

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Jah Yeon Choi et al.
The American journal of cardiology, 122(6), 922-928 (2018-09-16)
Although statin use in patients with acute myocardial infarction (AMI) is mandatory, it has been suggested to be associated with new-onset diabetes mellitus (NODM). In real world practice, moderate-intensity statin therapy is more commonly used than high-intensity statin therapy. In
Sheridan M Hoy
American journal of cardiovascular drugs : drugs, devices, and other interventions, 17(2), 157-168 (2017-01-29)
Oral pitavastatin (Livalo®; Livazo®) is a competitive HMG-CoA reductase inhibitor that is available in the EU for the reduction of elevated total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels in adults with primary hypercholesterolemia and combined (mixed) dyslipidemia. In short-term

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