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SML2473

Pitavastatin calcium

Name: Pitavastatin calcium
Brand: SIGMA

≥98% (HPLC), HMG CoA reductase inhibitor, powder

Synonym(s):

(+)monocalcium bis{(3R, 5S, 6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5dihydroxy-6-heptenoate}, (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid calcium salt

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About This Item

Empirical Formula (Hill Notation):

C₂₅H₂₃FNO₄ · 0.5Ca

CAS Number:

147526-32-7

Molecular Weight:

440.49

UNSPSC Code:

51111800

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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Properties

Product Name

Pitavastatin calcium, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +19 to +24°, c = 1 in acetonitrile: water (1:1)

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[Ca+2].Fc5ccc(cc5)c6c7c(nc(c6\C=C\[C@@H](O)C[C@@H](O)CC(=O)[O-])C8CC8)cccc7.Fc1ccc(cc1)c2c3c(nc(c2\C=C\[C@@H](O)C[C@@H](O)CC(=O)[O-])C4CC4)cccc3

InChI

1S/2C25H24FNO4.Ca/c2*26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31;/h2*1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31);/q;;+2/p-2/b2*12-11+;/t2*18-,19-;/m11./s1

InChI key

RHGYHLPFVJEAOC-FFNUKLMVSA-L

Description

Biochem/physiol Actions

HMG CoA reductase inhibitor

Pitavastatin calcium is a water-soluble inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Pitavastatin calcium is antilipidemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.

pictograms

GHS08

signalword

Warning

hcodes

H361f

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c