SML2500
Senicapoc
≥98% (HPLC)
Synonym(s):
4-fluoro-α-(4-fluorophenyl)-α-phenyl-Benzeneacetamide, ICA 17043
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About This Item
Empirical Formula (Hill Notation):
C20H15F2NO
CAS Number:
Molecular Weight:
323.34
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(N)C(C1=CC=C(F)C=C1)(C2=CC=C(F)C=C2)C3=CC=CC=C3
InChI
1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
InChI key
SCTZUZTYRMOMKT-UHFFFAOYSA-N
Biochem/physiol Actions
KCa3.1 channel blocker
Senicapoc (ICA-17043) is an inhibitor of the calcium-activated K+ channel KCa3.1, also known as the Gardos channel, which plays a role in K+ loss and dehydration of sickled red blood cells. Senicapoc blocks calcium-induced rubidium flux in human RBCs with and IC50 of 11 nM and prevents RBC dehydration in a transgenic mouse sickle cell disease model. It has been investigated for a number of possible uses, which include antimalarial activity, idiopathic pulmonary fibrosis, glioblastoma, lung cancer, non-alcoholic liver disease, hereditary xerocytosis, suppression of microglial activation in stroke, and immune system disorders.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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