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SML2501

MF-094

≥98% (HPLC)

Synonym(s):

(S)-N-(1-((5-(N-(tert-butyl)sulfamoyl)naphthalen-1-yl)amino)-1-oxo-3-phenylpropan-2-yl)cyclohexanecarboxamide

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About This Item

Empirical Formula (Hill Notation):
C30H37N3O4S
CAS Number:
2241025-68-1
Molecular Weight:
535.70
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD31813673
Assay:
≥98% (HPLC)
Form:
powder
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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(NC(C)(C)C)c1c2c(c(ccc2)NC(=O)[C@@H](NC(=O)C4CCCCC4)Cc3ccccc3)ccc1

InChI key

DQXORJHBZHLLTE-SANMLTNESA-N

Biochem/physiol Actions

Inhibitor of ubiquitin specific protease 30 (USP30)
MF-094 is a potent inhibitor of ubiquitin specific protease 30 (USP30), a de-ubiquitinating enzymes (DUB) that opposes the action of parkin-mediated ubiquitination in clearing damaged mitochondria. MF-094 is selective for USP30 with an IC50 value of 120 nM, compared to >10 μM for USPs 1, 8, and 9.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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