SML2514
Nedaplatin
Synonym(s):
Nedaplatin, Cis-Diammine (Glycolato)Platinum
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About This Item
Empirical Formula (Hill Notation):
C2H8N2O3Pt
CAS Number:
Molecular Weight:
303.17
UNSPSC Code:
12352200
NACRES:
NA.77
Form:
powder
form
powder
storage temp.
2-8°C
SMILES string
[Pt+2].[N-H2].[N-H2].OCC(=O)O
InChI
1S/C2H4O3.2H2N.Pt/c3-1-2(4)5;;;/h3H,1H2,(H,4,5);2*1H2;/q;2*-1;+2
InChI key
KLNFSAOEKUDMFA-UHFFFAOYSA-N
Biochem/physiol Actions
Nedaplatin is a second-generation cisplatin analog with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. Nedplatin is less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin.
signalword
Danger
Hazard Classifications
Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Resp. Sens. 1B - Skin Irrit. 2 - Skin Sens. 1B - STOT SE 3
target_organs
Respiratory system
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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