SML2527
SW063058
≥98% (HPLC)
Synonym(s):
7-Bromo-5-(4-fluorophenyl)-1,3,4,5-tetrahydro-4-(2-iodobenzoyl)-2H-1,4-benzodiazepin-2-one
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About This Item
Empirical Formula (Hill Notation):
C22H15BrFIN2O2
CAS Number:
Molecular Weight:
565.17
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
Ic1c(cccc1)C(=O)N2C(c4c(ccc(c4)Br)NC(=O)C2)c3ccc(cc3)F
InChI
1S/C22H15BrFIN2O2/c23-14-7-10-19-17(11-14)21(13-5-8-15(24)9-6-13)27(12-20(28)26-19)22(29)16-3-1-2-4-18(16)25/h1-11,21H,12H2,(H,26,28)
InChI key
CFXZDEOFOAXVPQ-UHFFFAOYSA-N
Biochem/physiol Actions
Autophagy inducer that selectively disrupts Beclin 1/Bcl-2 binding
SW063058 is an autophagy inducer that selectively disrupts Beclin 1/Bcl-2 binding, versus Bax/Bcl-2 binding. SW063058 acts by disrupting the binding of Bcl-2, a negative regulator of autophagy, to the BH3 domain of Beclin 1, which is involved in autophagy initiation. It does not inhibit Bcl-2 binding to the BH3 domain of the pro-apoptotic Bcl-2 family members BAX and BIM. In vitro experiments showed that SW063058 was not cytotoxic and induced autophagy without inducing apoptosis or other forms of cell death.
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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