SML2528
K-TMZ
≥98% (HPLC)
Synonym(s):
8-Acetyl-3-methylimidazo[5,1-d][1,2,3,5]tetrazin-4(3H)-one
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About This Item
Empirical Formula (Hill Notation):
C7H7N5O2
CAS Number:
Molecular Weight:
193.16
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CC(C(N=C1)=C2N1C(N(C)N=N2)=O)=O
InChI
1S/C7H7N5O2/c1-4(13)5-6-9-10-11(2)7(14)12(6)3-8-5/h3H,1-2H3
InChI key
QXYCTGXCOQXVRU-UHFFFAOYSA-N
Biochem/physiol Actions
K-TMZ is a more potent, more brain-penetrable, less toxic analog of temozolomide (TMZ). It showed superior activity to TMZ in a mouse model of glioblastoma with significantly less myelotoxicity.
Less toxic analog of temozolomide with more potent anticancer activity
signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Muta. 2 - Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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