SML2531
TH5487
≥98% (HPLC)
Synonym(s):
4-(4-Bromo-2-oxo-3H-benzimidazol-1-yl)-N-(4-iodophenyl)piperidine-1-carboxamide
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About This Item
Empirical Formula (Hill Notation):
C19H18BrIN4O2
CAS Number:
Molecular Weight:
541.18
UNSPSC Code:
12352200
NACRES:
NA.77
SMILES string
IC1=CC=C(NC(N2CCC(N(C3=CC=CC(Br)=C3N4)C4=O)CC2)=O)C=C1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
Inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)
TH5487 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1), which is part of the DNA base excision repair pathway. TH5487 as shown to inhibit OGG1-dependent proinflammatory gene expression by binding in the OGG1 active site, preventing OGG1 from engaging damaged DNA in vitro and in cells, resulting in decreased proinflammatory gene expression.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Torkild Visnes et al.
Science (New York, N.Y.), 362(6416), 834-839 (2018-11-18)
The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA. Because 8-oxoguanine DNA glycosylase 1 (OGG1) binds 8-oxoG and because Ogg1-deficient mice are resistant to acute and systemic inflammation, we
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