SML2531
TH5487
≥98% (HPLC)
别名:
4-(4-Bromo-2-oxo-3H-benzimidazol-1-yl)-N-(4-iodophenyl)piperidine-1-carboxamide
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关于此项目
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
IC1=CC=C(NC(N2CCC(N(C3=CC=CC(Br)=C3N4)C4=O)CC2)=O)C=C1
Biochem/physiol Actions
Inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1)
TH5487 is an inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1), which is part of the DNA base excision repair pathway. TH5487 as shown to inhibit OGG1-dependent proinflammatory gene expression by binding in the OGG1 active site, preventing OGG1 from engaging damaged DNA in vitro and in cells, resulting in decreased proinflammatory gene expression.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable