SML2533
Jedi1
≥98% (HPLC), Piezo1 channel activator, powder
Synonym(s):
2-Methyl-5-phenyl-3-furancarboxylic acid, 2-Methyl-5-phenyl-3-furoic acid, 2-Methyl-5-phenylfuran-3-carboxylic acid, 5-Phenyl-2-methyl-3-furancarboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C12H10O3
CAS Number:
Molecular Weight:
202.21
UNSPSC Code:
12352302
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Product Name
Jedi1, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
[O-]C(=O)c1c([o]c(c1)c2ccccc2)C
InChI
1S/C12H10O3/c1-8-10(12(13)14)7-11(15-8)9-5-3-2-4-6-9/h2-7H,1H3,(H,13,14)/p-1
InChI key
VLMNACSEESRUAK-UHFFFAOYSA-M
Biochem/physiol Actions
Jedi1 is an activator of the mechanosensitive Piezo1 channel that binds at a different place from Yoda1. It exhibits long-range allosteric gating, activating Piezo1 through the extracellular side of its peripheral blade-like structure rather than the C-terminal extracellular domain of the pore.
Piezo1 channel activator
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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