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Merck
CN

SML2533

Jedi1

≥98% (HPLC), Piezo1 channel activator, powder

Synonym(s):

2-Methyl-5-phenyl-3-furancarboxylic acid, 2-Methyl-5-phenyl-3-furoic acid, 2-Methyl-5-phenylfuran-3-carboxylic acid, 5-Phenyl-2-methyl-3-furancarboxylic acid

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About This Item

Empirical Formula (Hill Notation):
C12H10O3
CAS Number:
108124-17-0
Molecular Weight:
202.21
UNSPSC Code:
12352302
NACRES:
NA.77

Key Documents

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Product Name

Jedi1, ≥98% (HPLC)

SMILES string

[O-]C(=O)c1c([o]c(c1)c2ccccc2)C

InChI

1S/C12H10O3/c1-8-10(12(13)14)7-11(15-8)9-5-3-2-4-6-9/h2-7H,1H3,(H,13,14)/p-1

InChI key

VLMNACSEESRUAK-UHFFFAOYSA-M

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Related Categories

Biochem/physiol Actions

Jedi1 is an activator of the mechanosensitive Piezo1 channel that binds at a different place from Yoda1. It exhibits long-range allosteric gating, activating Piezo1 through the extracellular side of its peripheral blade-like structure rather than the C-terminal extracellular domain of the pore.
Piezo1 channel activator

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000474891
0000474889
0000474889
0000474891
0000380049

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