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Merck
CN

SML2536

MRK-740-NC

≥98% (HPLC)

Synonym(s):

4-(3-(3,5-Dimethoxy-phenyl)-1,2,4-oxadiazol-5-yl)-1-methyl-9-phenyl-1,4,9-triaza-spiro[5.5]undecane

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About This Item

Empirical Formula (Hill Notation):
C25H31N5O3
CAS Number:
2421146-31-6
Molecular Weight:
449.55
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

Key Documents

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Product Name

MRK-740-NC, ≥98% (HPLC)

InChI

1S/C25H31N5O3/c1-28-13-14-30(18-25(28)9-11-29(12-10-25)20-7-5-4-6-8-20)24-26-23(27-33-24)19-15-21(31-2)17-22(16-19)32-3/h4-8,15-17H,9-14,18H2,1-3H3

InChI key

OACWMVMQWRVMAF-UHFFFAOYSA-N

SMILES string

CN1CCN(C2=NC(C3=CC(OC)=CC(OC)=C3)=NO2)CC14CCN(C5=CC=CC=C5)CC4

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

MRK-740-NC is a very weak inhibitor of the in vitro methylation of H3K4 that can serve as negative control for MRK-740 a potent and selective inhibitor of histone methyltransferases PRDM9.
negative control for MRK-740 a potent and selective inhibitor of histone methyltransferases PRDM9

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000088970
0000088971
0000075206

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Abdellah Allali-Hassani et al.
Nature communications, 10(1), 5759-5759 (2019-12-19)
PRDM9 is a PR domain containing protein which trimethylates histone 3 on lysine 4 and 36. Its normal expression is restricted to germ cells and attenuation of its activity results in altered meiotic gene transcription, impairment of double-stranded breaks and

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