SML2546
GLX351322
≥98% (HPLC)
Synonym(s):
2-[[2-[4-(2-Furanylcarbonyl)-1-piperazinyl]acetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid ethyl ester
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About This Item
Empirical Formula (Hill Notation):
C21H25N3O5S
CAS Number:
Molecular Weight:
431.51
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI key
KEVHLTCEMHIJTQ-UHFFFAOYSA-N
SMILES string
O=C(C1=C(NC(CN2CCN(C(C3=CC=CO3)=O)CC2)=O)SC4=C1CCC4)OCC
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
GLX351322 is a potent and selective inhibitor of NOX4 (NADPH oxidase 4). GLX351322 prevents ROS generation and cellular death, improves pancreatic beta cell function in high-fat diet fed C57Bl/6 mice.
potent and selective inhibitor of NOX4 (NADPH oxidase 4)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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E Anvari et al.
Free radical research, 49(11), 1308-1318 (2015-06-30)
In type 2 diabetes, it has been proposed that pancreatic beta-cell dysfunction is promoted by oxidative stress caused by NADPH oxidase (NOX) overactivity. Five different NOX enzymes (NOX1-5) have been characterized, among which NOX1 and NOX2 have been proposed to
Qing-Liang Wen et al.
Molecular and cellular endocrinology, 523, 111144-111144 (2021-01-01)
In this study, we aimed to clarify the role of PIM-1 in papillary thyroid carcinoma (PTC) in vitro and investigate the relationship between PIM-1 and redox proteins (NOX4, SOD2, and GPX2) at the tissue and cellular levels. As a PIM-1
Xuan Wang et al.
PloS one, 13(9), e0204271-e0204271 (2018-09-29)
It has been proposed that pancreatic beta-cell dysfunction in type 2 diabetes is promoted by oxidative stress caused by NADPH oxidase (Nox) over-activity. The aim of the present study was to evaluate the efficacy of novel Nox inhibitors as protective
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