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SML2547

KCC-07

≥98% (HPLC)

Synonym(s):

3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol

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About This Item

Empirical Formula (Hill Notation):
C14H11N3OS
CAS Number:
315702-75-1
Molecular Weight:
269.32
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD01121976
Assay:
≥98% (HPLC)
Form:
powder
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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

OC1=CC(NC2=NC(C3=NC=CC=C3)=CS2)=CC=C1

InChI key

GIGNWEDIMLUWCT-UHFFFAOYSA-N

Biochem/physiol Actions

KCC-07 is a brain penetrant, potent and selective inhibitor of MBD2 (methyl-CpG-binding domain protein 2) that inhibits binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. KCC-07 inhibits medulloblastoma cell proliferation, and inhibits tumor growth in mice xenograft models of medulloblastoma.
brain penetrant, potent and selective inhibitor of MBD2 that inducing anti-proliferative BAI1/p53/p21 signaling

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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