SML2547
KCC-07
≥98% (HPLC)
Synonym(s):
3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol
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About This Item
Empirical Formula (Hill Notation):
C14H11N3OS
CAS Number:
Molecular Weight:
269.32
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI key
GIGNWEDIMLUWCT-UHFFFAOYSA-N
SMILES string
OC1=CC(NC2=NC(C3=NC=CC=C3)=CS2)=CC=C1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
KCC-07 is a brain penetrant, potent and selective inhibitor of MBD2 (methyl-CpG-binding domain protein 2) that inhibits binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1) inducing anti-proliferative BAI1/p53/p21 signaling. KCC-07 inhibits medulloblastoma cell proliferation, and inhibits tumor growth in mice xenograft models of medulloblastoma.
brain penetrant, potent and selective inhibitor of MBD2 that inducing anti-proliferative BAI1/p53/p21 signaling
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Dan Zhu et al.
Cancer cell, 33(6), 1004-1016 (2018-06-13)
Adhesion G protein-coupled receptors (ADGRs) encompass 33 human transmembrane proteins with long N termini involved in cell-cell and cell-matrix interactions. We show the ADGRB1 gene, which encodes Brain-specific angiogenesis inhibitor 1 (BAI1), is epigenetically silenced in medulloblastomas (MBs) through a methyl-CpG
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