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Merck
CN

SML2548

Sigma-Aldrich

MS094

≥98% (HPLC)

Synonym(s):

2-[Methyl[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]amino]-ethanol

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About This Item

Empirical Formula (Hill Notation):
C17H24N2O2
CAS Number:
1831110-55-4
Molecular Weight:
288.38
UNSPSC Code:
51111800
NACRES:
NA.77

Key Documents

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Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN(CCO)CC1=CNC=C1C2=CC=C(OC(C)C)C=C2

InChI

1S/C17H24N2O2/c1-13(2)21-16-6-4-14(5-7-16)17-11-18-10-15(17)12-19(3)8-9-20/h4-7,10-11,13,18,20H,8-9,12H2,1-3H3

InChI key

GNAKYUUZAXUXKB-UHFFFAOYSA-N

Biochem/physiol Actions

Inactive control probe for PRMT inhibitor MS023
MS094 i an inactive control probe for PRMT inhibitor MS023. MS023 is a potent and selective chemical probe for Type I protein arginine methyltransferases (PRMTs) 1,3,4,6,and 8, which are responsible for asymmetric dimethylation of arginine residues. MS023 is active in cells.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000188849
0000188849
0000066872
0000066873
0000060620

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Reduced C9orf72 expression exacerbates polyGR toxicity in patient iPSC-derived motor neurons and a Type I protein arginine methyltransferase inhibitor reduces that toxicity.
Dane, et al.
Frontiers in Cellular Neuroscience, 17, 1134090-1134090 (2023)
Mohammad S Eram et al.
ACS chemical biology, 11(3), 772-781 (2015-11-26)
Protein arginine methyltransferases (PRMTs) play a crucial role in a variety of biological processes. Overexpression of PRMTs has been implicated in various human diseases including cancer. Consequently, selective small-molecule inhibitors of PRMTs have been pursued by both academia and the

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