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Merck
CN

SML2556

Pt-ttpy

>97% (NMR)

Synonym(s):

(SP-4-2)-Chloro[4′-(4-methylphenyl)-2,2′:6′,2′′-terpyridine-κN1,κN1′,κN1′′]-Platinum(1+) chloride, Tolylterpyridin-platin

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About This Item

Empirical Formula (Hill Notation):
C22H17Cl2N3Pt
CAS Number:
727721-37-1
Molecular Weight:
589.37
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

Pt-ttpy, >97% (NMR)

form

powder

InChI

1S/C22H17N3.2ClH.Pt/c1-16-8-10-17(11-9-16)18-14-21(19-6-2-4-12-23-19)25-22(15-18)20-7-3-5-13-24-20;;;/h2-15H,1H3;2*1H;/q;;;+2/p-2

InChI key

UWAUJHRZLKCPPX-UHFFFAOYSA-L

SMILES string

CC1=CC=C(C2=CC(C3=[N+]4C=CC=C3)=[N+]5C(C6=CC=CC=[N+]6[Pt-2]54Cl)=C2)C=C1.[Cl-]

assay

>97% (NMR)

color

faint yellow to dark orange

solubility

DMSO: 0.2 mg/mL (warmed)

storage temp.

2-8°C

Biochem/physiol Actions

G-quadruplex ligand that potently induces significant telomere-associated DNA damage in cancer cells
Pt-ttpy, a metallo-organic complex, is a G-quadruplex ligand that potently induces significant telomere-associated DNA damage in cancer cells. It inhibits telomerase and/or telomere functions. Pt-ttpy induces number of chromatin defects in mitosis including chromatin bridges, ultrafine bridges (UFBs), and double-stranded breaks (DSBs).

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000069892
0000069893
0000065655

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