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Merck
CN

SML2582

LDK1305

≥98% (HPLC)

Synonym(s):

1-(4-Cyanophenyl)-3-(3-(6-(pyrrolidin-1-yl)pyridin-2-yl)phenyl)urea, N-(4-Cyanophenyl)-N′-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]-urea

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About This Item

Empirical Formula (Hill Notation):
C23H21N5O
CAS Number:
1626414-51-4
Molecular Weight:
383.45
UNSPSC Code:
12352200
NACRES:
NA.77

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InChI

1S/C23H21N5O/c24-16-17-9-11-19(12-10-17)25-23(29)26-20-6-3-5-18(15-20)21-7-4-8-22(27-21)28-13-1-2-14-28/h3-12,15H,1-2,13-14H2,(H2,25,26,29)

InChI key

HWIMBWAXFAEZQR-UHFFFAOYSA-N

SMILES string

O=C(NC1=CC=C(C=C1)C#N)NC2=CC(C3=CC=CC(N4CCCC4)=N3)=CC=C2

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

selective positive allosteric modulator of CB1; a beta-arrestin-biased ligand
LDK1305 is a selective positive allosteric modulator of CB1 that promote the binding of the agonist CP55940 and inhibits binding of orthosteric inverse agonist SR141716A. LDK1305 is a beta-arrestin-biased ligand that induces cellular internalization of the receptor and recruitment of β-arrestin 2 in HEK293 cells. It stimulates also β-arrestin 1-dependent phosphorylation of the downstream kinases, ERK1/2, MEK, and Src.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000073585
0000073587
0000071551

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