SML2582
LDK1305
≥98% (HPLC)
别名:
1-(4-Cyanophenyl)-3-(3-(6-(pyrrolidin-1-yl)pyridin-2-yl)phenyl)urea, N-(4-Cyanophenyl)-N′-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]-urea
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C(NC1=CC=C(C=C1)C#N)NC2=CC(C3=CC=CC(N4CCCC4)=N3)=CC=C2
InChI
1S/C23H21N5O/c24-16-17-9-11-19(12-10-17)25-23(29)26-20-6-3-5-18(15-20)21-7-4-8-22(27-21)28-13-1-2-14-28/h3-12,15H,1-2,13-14H2,(H2,25,26,29)
InChI key
HWIMBWAXFAEZQR-UHFFFAOYSA-N
生化/生理作用
LDK1305 is a selective positive allosteric modulator of CB1 that promote the binding of the agonist CP55940 and inhibits binding of orthosteric inverse agonist SR141716A. LDK1305 is a beta-arrestin-biased ligand that induces cellular internalization of the receptor and recruitment of β-arrestin 2 in HEK293 cells. It stimulates also β-arrestin 1-dependent phosphorylation of the downstream kinases, ERK1/2, MEK, and Src.
selective positive allosteric modulator of CB1; a beta-arrestin-biased ligand
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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