SML2630
Intronistat B hydrobromide
≥98% (HPLC)
Synonym(s):
N-(2-(Pyrrolidin-1-yl)ethyl)-2-(3,4,5-trihydroxybenzoyl) benzofuran-5-carboxamide hydrobromide
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
Empirical Formula (Hill Notation):
C22H22N2O6 · xHBr
Molecular Weight:
410.42 (free base basis)
NACRES:
NA.77
UNSPSC Code:
51111800
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
Product Name
Intronistat B hydrobromide, ≥98% (HPLC)
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to dark gray
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
Inhibitor of the self-splicing group IIB intron found in fungi
Intronistat B is a potent inhibitor of the self-splicing group IIB intron, a mitochondrial RNA tertiary structure necessary for respiration in fungi, yeast and plants, but not found in vertebrates. Intronistat B was found to have antifungal activity comparable to that of amphotericin B in inhibiting growth of the Candida parapsilosis. It did not inhibit spliceosomal processing, group I intron splicing or splicing of group II introns from subclasses other than subclass IIB and was not toxic to human cells.
Storage Class
11 - Combustible Solids
wgk
WGK 3
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Olga Fedorova et al.
Nature chemical biology, 14(12), 1073-1078 (2018-10-17)
Specific RNA structures control numerous metabolic processes that impact human health, and yet efforts to target RNA structures de novo have been limited. In eukaryotes, the self-splicing group II intron is a mitochondrial RNA tertiary structure that is absent in
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service