SML2637
NPD8733
≥98% (HPLC)
Synonym(s):
N-[2-(4-Methoxybenzoyl)-3-benzofuranyl]acetamide
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About This Item
Empirical Formula (Hill Notation):
C18H15NO4
CAS Number:
Molecular Weight:
309.32
UNSPSC Code:
12352200
NACRES:
NA.77
Product Name
NPD8733, ≥98% (HPLC)
SMILES string
N(c1c2c([o]c1C(=O)c3ccc(cc3)OC)cccc2)C(=O)C
InChI key
NQZBUYPGHZTWIR-UHFFFAOYSA-N
InChI
1S/C18H15NO4/c1-11(20)19-16-14-5-3-4-6-15(14)23-18(16)17(21)12-7-9-13(22-2)10-8-12/h3-10H,1-2H3,(H,19,20)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. NPD8733 binds to valosin-containing protein (VCP)/p97.
inhibitor of cancer cell-enhanced fibroblast migration
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Kruthi Suvarna et al.
The Journal of biological chemistry, 294(9), 2988-2996 (2019-01-06)
Carcinoma-associated fibroblasts are fibroblasts activated by surrounding cancer cells. Carcinoma-associated fibroblasts exhibit enhanced cell migration, which plays an important role in cancer metastasis. Previously, we demonstrated enhanced migration of NIH3T3 fibroblasts when they were cultured in the presence of MCF7
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