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SML2643

ML365

≥98% (HPLC)

Synonym(s):

2-Methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide, ML 365, ML365

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About This Item

Empirical Formula (Hill Notation):
C22H20N2O3
CAS Number:
947914-18-3
Molecular Weight:
360.41
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD09204310
Assay:
≥98% (HPLC)
Form:
powder
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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

N(c2cc(ccc2)NC(=O)c3cc(ccc3)C)C(=O)c1c(cccc1)OC

InChI

1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)

InChI key

UTAJHKSGYJSZBR-UHFFFAOYSA-N

Biochem/physiol Actions

Orignially characterized as an mGluR5 negative allosteric modulator (IC50 = 1.35 μM, Emax = 3.82% of Glu Emax; rat mGluR5 HEK293A cells), ML365 is now better known as selective two-pore potassium (K2P) channel TASK1 (K2P3.1; KCNK3) inhibitor with 100- and 62-fold selectivity over TASK3 (K2p9.1; KCNK9), respectively, by thellium flux (rat TASK1/TASK3 CHO cell IC50 = 4/390 nM) and QPatch assay (rat TASK1/TASK3 CHO cell IC50 = 16/990 nM). ML365 is employed in the range from 40 nM to 20 μM. Selective TASK1 blockage is achieved at the lower end of the concentration range, while TASK3 activity can also be inhibited at the high end of the range.
Selective two-pore potassium (K2P) channel TASK1 (K2P3.1; KCNK3) inhibitor with 62- to 100-fold selectivity over TASK3 (K2p9.1; KCNK9).

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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