SML2644
NCGC00135472
≥98% (HPLC)
Synonym(s):
3,4-Difluoro-N-[3-(3-methylimidazo[1,2-a]pyrimidin-2-yl)phenyl]-benzamide, C2A
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About This Item
Empirical Formula (Hill Notation):
C20H14F2N4O
CAS Number:
Molecular Weight:
364.35
UNSPSC Code:
12352200
NACRES:
NA.77
Assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
room temp
SMILES string
Fc1c(ccc(c1)C(=O)Nc2cc(ccc2)c3nc4[n](c3C)cccn4)F
InChI
1S/C20H14F2N4O/c1-12-18(25-20-23-8-3-9-26(12)20)13-4-2-5-15(10-13)24-19(27)14-6-7-16(21)17(22)11-14/h2-11H,1H3,(H,24,27)
InChI key
YOVZCQZBMAXLPR-UHFFFAOYSA-N
Biochem/physiol Actions
NCGC00135472 (C2A) is a resolvin D1 (RvD1) mimetic that activates resolving D1 receptor (DRV1/GPR32) and stimulate phagocytosis of serum-treated zymosan. NCGC00135472 enhances macrophage phagocytosis of live E. coli.
resolvin D1 (RvD1) mimetic that activates DRV1/GPR32
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Nan Chiang et al.
Cell chemical biology, 26(2), 244-254 (2018-12-18)
Resolution of acute inflammation is governed, in part, by specialized pro-resolving mediators, including lipoxins, resolvins, protectins, and maresins. Among them, resolvin D1 (RvD1) exhibits potent pro-resolving functions via activating human resolvin D1 receptor (DRV1/GPR32). RvD1 is a complex molecule that requires
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