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Merck
CN

SML2647

CA3

≥97% (HPLC)

Synonym(s):

1,1′-[[9-(Hydroxyimino)-9H-fluorene-2,7-diyl]bis(sulfonyl)]bis-piperidine, 2,7-bis(1-Piperidinylsulfonyl)-9H-fluoren-9-one oxime, CIL56

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About This Item

Empirical Formula (Hill Notation):
C23H27N3O5S2
CAS Number:
300802-28-2
Molecular Weight:
489.61
MDL number:
MFCD00323348
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Assay

≥97% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

[S](=O)(=O)(N5CCCCC5)c1cc2c(cc1)c3c(cc(cc3)[S](=O)(=O)N4CCCCC4)C2N=O

InChI

1S/C23H27N3O5S2/c27-24-23-21-15-17(32(28,29)25-11-3-1-4-12-25)7-9-19(21)20-10-8-18(16-22(20)23)33(30,31)26-13-5-2-6-14-26/h7-10,15-16,23H,1-6,11-14H2

InChI key

YLRXSLQNJCJWGZ-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

CA3 is a potent and selective inhibitor of YAP1 (Hippo co-activator Yes-associated protein 1) that inhibits YAP1 expression and transcriptional activity in esophageal adenocarcinoma (EAC) cell lines. CA3 potently inhibits growth, induces apoptosis in radiation resistant CSC (cancer stem cell) enriched EAC cells. It inhibits tumor growth of in xenograft model with no apparent toxicity.
potent and selective inhibitor of YAP1 that inhibits YAP1 expression and transcriptional activity in EAC cell lines

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
0000144728
0000144730
0000144728
0000077823

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Shumei Song et al.
Molecular cancer therapeutics, 17(2), 443-454 (2017-11-24)
Mounting evidence suggests that the Hippo coactivator Yes-associated protein 1 (YAP1) is a major mediator of cancer stem cell (CSC) properties, tumor progression, and therapy resistance as well as often a terminal node of many oncogenic pathways. Thus, targeting YAP1
Siyuan Hao et al.
iScience, 27(6), 109927-109927 (2024-05-24)
YAP/TEAD signaling is essential for organismal development, cell proliferation, and cancer progression. As a transcriptional coactivator, how YAP activates its downstream target genes is incompletely understood. YAP forms biomolecular condensates in response to hyperosmotic stress, concentrating transcription-related factors to activate
Xiao Qin et al.
Cell, 186(25), 5554-5568 (2023-12-09)
Cancer cells are regulated by oncogenic mutations and microenvironmental signals, yet these processes are often studied separately. To functionally map how cell-intrinsic and cell-extrinsic cues co-regulate cell fate, we performed a systematic single-cell analysis of 1,107 colonic organoid cultures regulated
Sina Stern et al.
Neuron, 109(21), 3436-3455 (2021-09-12)
An inhibitory extracellular milieu and neuron-intrinsic processes prevent axons from regenerating in the adult central nervous system (CNS). Here we show how the two aspects are interwoven. Genetic loss-of-function experiments determine that the small GTPase RhoA relays extracellular inhibitory signals

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