SML2647
CA3
≥97% (HPLC)
Synonym(s):
1,1′-[[9-(Hydroxyimino)-9H-fluorene-2,7-diyl]bis(sulfonyl)]bis-piperidine, 2,7-bis(1-Piperidinylsulfonyl)-9H-fluoren-9-one oxime, CIL56
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C23H27N3O5S2
CAS Number:
Molecular Weight:
489.61
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
powder
assay
≥97% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
[S](=O)(=O)(N5CCCCC5)c1cc2c(cc1)c3c(cc(cc3)[S](=O)(=O)N4CCCCC4)C2N=O
InChI
1S/C23H27N3O5S2/c27-24-23-21-15-17(32(28,29)25-11-3-1-4-12-25)7-9-19(21)20-10-8-18(16-22(20)23)33(30,31)26-13-5-2-6-14-26/h7-10,15-16,23H,1-6,11-14H2
InChI key
YLRXSLQNJCJWGZ-UHFFFAOYSA-N
Biochem/physiol Actions
CA3 is a potent and selective inhibitor of YAP1 (Hippo co-activator Yes-associated protein 1) that inhibits YAP1 expression and transcriptional activity in esophageal adenocarcinoma (EAC) cell lines. CA3 potently inhibits growth, induces apoptosis in radiation resistant CSC (cancer stem cell) enriched EAC cells. It inhibits tumor growth of in xenograft model with no apparent toxicity.
potent and selective inhibitor of YAP1 that inhibits YAP1 expression and transcriptional activity in EAC cell lines
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.