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Merck
CN

SML2659

Spastazoline

≥98% (HPLC)

Synonym(s):

(R)-N-(5-(tert-butyl)-1H-pyrazol-3-yl)-2-(3-isopropylpiperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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About This Item

Empirical Formula (Hill Notation):
C20H30N8
CAS Number:
2351882-11-4
Molecular Weight:
382.51
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD31813810

Key Documents

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SMILES string

[nH]1nc(cc1Nc2nc(nc4[nH]ccc42)N3C[C@H](NCC3)C(C)C)C(C)(C)C

InChI

1S/C20H30N8/c1-12(2)14-11-28(9-8-21-14)19-24-17-13(6-7-22-17)18(25-19)23-16-10-15(26-27-16)20(3,4)5/h6-7,10,12,14,21H,8-9,11H2,1-5H3,(H3,22,23,24,25,26,27)/t14-/m0/s1

InChI key

HNOLTAKAPDKZRY-AWEZNQCLSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Related Categories

Biochem/physiol Actions

Spastazoline is a cell penetrant, potent and selective ATP-competitive inhibitor of spastin.
cell penetrant, potent and selective ATP-competitive inhibitor of spastin

Storage Class

11 - Combustible Solids

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000097787
0000097789
0000083325

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Rudolf Pisa et al.
Journal of the American Chemical Society, 141(14), 5602-5606 (2019-03-16)
The bump-hole approach is a powerful chemical biology strategy to specifically probe the functions of closely related proteins. However, for many protein families, such as the ATPases associated with diverse cellular activities (AAA), we lack structural data for inhibitor-protein complexes
Tommaso Cupido et al.
Nature chemical biology, 15(5), 444-452 (2019-02-20)
Spastin is a microtubule-severing AAA (ATPases associated with diverse cellular activities) protein needed for cell division and intracellular vesicle transport. Currently, we lack chemical inhibitors to probe spastin function in such dynamic cellular processes. To design a chemical inhibitor of

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