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SML2662

SPA70

Name: SPA70
Brand: SIGMA

≥98% (HPLC), human pregnane X receptor antagonist, powder

Synonym(s):

1-(2,5-Dimethoxyphenyl)-4-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-5-methyl-1H-12,3-triazole, LC-1

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₅N₃O₄S

CAS Number:

931314-31-7

Molecular Weight:

415.51

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD14774311

Assay:

≥98% (HPLC)

Form:

powder

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Properties

Product Name

SPA70, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(c2nn[n](c2C)c3c(ccc(c3)OC)OC)c1ccc(cc1)C(C)(C)C

InChI key

OIOPHIFJQXHPAF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

SPA70 is a cell penetrant, potent and highly selective human pregnane X receptor (hPXR) antagonist that inhibits hPXR in humanized mouse models. It inhibits hPXR-mediated drug metabolism in in primary human hepatocytes and in mouse models.

cell penetrant, potent and highly selective human pregnane X receptor (hPXR) antagonist that inhibits hPXR in humanized mouse models.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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