SML2664
GNF-4877
≥98% (HPLC)
Synonym(s):
(3R)-1-[3-[[[3-Amino-6-[2-fluoro-5-(1-methylethoxy)phenyl]-2-pyrazinyl]carbonyl]amino]-4-pyridinyl]-3-piperidinecarboxylic acid, GNF 4877
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C25H27FN6O4
CAS Number:
Molecular Weight:
494.52
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
faint yellow to dark orange
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
NC1=NC=C(C2=CC(OC(C)C)=CC=C2F)N=C1C(NC3=CN=CC=C3N4C[C@H](C(O)=O)CCC4)=O
InChI
1S/C25H27FN6O4/c1-14(2)36-16-5-6-18(26)17(10-16)19-12-29-23(27)22(30-19)24(33)31-20-11-28-8-7-21(20)32-9-3-4-15(13-32)25(34)35/h5-8,10-12,14-15H,3-4,9,13H2,1-2H3,(H2,27,29)(H,31,33)(H,34,35)/t15-/m1/s1
InChI key
UZIATSFXNVOVFE-OAHLLOKOSA-N
Biochem/physiol Actions
GNF-4877 is an orally available dual inhibitor of Dyrk1a and Gsk3b that induces proliferation of functional primary human and rodent β-cells. GNF4877 reduces non-fasting blood glucose levels in a mouse model of T1D.
orally available dual inhibitor of Dyrk1a and Gsk3b that induces proliferation of functional primary human and rodent β-cells
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.