SML2675
CuET
≥97% (HPLC)
Synonym(s):
Copper bis(N,N-diethyldithiocarbamate), Cupric diethyldithiocarbamate, Merkupral, NSC 177697, bis(N,N-Diethyldithiocarbamato)copper(II)
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About This Item
Empirical Formula (Hill Notation):
C10H20CuN2S4
CAS Number:
Molecular Weight:
360.09
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Product Name
CuET, ≥97% (HPLC)
InChI
1S/2C5H11NS2.Cu/c2*1-3-6(4-2)5(7)8;/h2*3-4H2,1-2H3,(H,7,8);/q;;+2/p-2
SMILES string
CCN(CC)C(S[Cu]SC(N(CC)CC)=S)=S
InChI key
OBBCYCYCTJQCCK-UHFFFAOYSA-L
assay
≥97% (HPLC)
form
powder
storage condition
desiccated
color
dark green to black
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Related Categories
Biochem/physiol Actions
CuET, a metabolite of disulfiram, is an inhibitor of p97 segregase adaptor NPL4 that exhibits potent anti-cancer effects. Apparently CuET binds NPL4 and induces its aggregation, which disables the vital p97–NPL4–UFD1 pathway and induces to cell death.
Inhibitor of NPL4
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Tomoya Fujie et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 21(2), 263-273 (2016-01-31)
The interest in organic-inorganic hybrid molecules as molecular probes for biological systems has been growing rapidly. Such hybrid molecules exhibit unique biological activities. Herein, copper(II) bis(diethyldithiocarbamate) (Cu10) was found to activate the transcription factor NF-E2-related factor 2 (Nrf2), which is
Zdenek Skrott et al.
Nature, 552(7684), 194-199 (2017-12-07)
Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need for improved cancer treatment is drug repurposing. Here we highlight the potential for repurposing disulfiram (also
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