SML2712
ES9-17
≥98% (HPLC), clathrin-mediated endocytosis (CME) inhibitor, powder
Synonym(s):
5-Bromo-2-thiophenesulfonanilide, 5-Bromo-N-phenyl-2-thiophenesulfonamide
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About This Item
Empirical Formula (Hill Notation):
C10H8BrNO2S2
CAS Number:
Molecular Weight:
318.21
UNSPSC Code:
12352200
NACRES:
NA.77
Product Name
ES9-17, ≥98% (HPLC)
InChI key
AIZXCKZVUXCHAP-UHFFFAOYSA-N
SMILES string
O=S(NC1=CC=CC=C1)(C2=CC=C(S2)Br)=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
Related Categories
Biochem/physiol Actions
ES9-17 is a potent and selective inhibitor of clathrin-mediated endocytosis (CME) that binds to N-terminal domain of clathrin heavy chain. ES9-17 inhibits uptake of different endocytic cargoes in Arabidopsis and HeLa cells.
potent and selective inhibitor of clathrin-mediated endocytosis (CME)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Wim Dejonghe et al.
Nature chemical biology, 15(6), 641-649 (2019-04-24)
Clathrin-mediated endocytosis (CME) is a highly conserved and essential cellular process in eukaryotic cells, but its dynamic and vital nature makes it challenging to study using classical genetics tools. In contrast, although small molecules can acutely and reversibly perturb CME
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