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Merck
CN

SML2721

GSK8612

≥98% (HPLC)

Synonym(s):

4-(((5-Bromo-2-((3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)amino)methyl)benzenesulfonamide, 4-((5-Bromo-2-(3-methyl-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-ylamino)pyrimidin-4-ylamino)methyl)benzenesulfonamide, GSK 8612, GSK-8612

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About This Item

Empirical Formula (Hill Notation):
C17H17BrF3N7O2S
CAS Number:
2361659-62-1
Molecular Weight:
520.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD32062739

Key Documents

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SMILES string

FC(F)(F)C[n]1nc(c(c1)Nc2nc(c(cn2)Br)NCc3ccc(cc3)[S](=O)(=O)N)C

InChI key

FFPHMUIGESPOTK-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

GSK8612 is a potent and highly selective tank-binding kinase-1 (TBK1) inhibitor (pIC50 = 6.8; pKd = 8.0 vs pKa = 6.2/STK17B, 6.0/IKKε, 6.1/LRRK2, 6.0/FLT4, 5.8/ULK3, 5.7/BMP2K, 5.7/CSNK2A1, 5.6/CSNK2A2, 5.6/FLT4, 5.5/PIK3CD, <5.5/more than 270 kinases). GSK8612 inhibits IFNβ secretion induced by dsDNA containing virus or STING ligand cGAMP (IC50 = 1.25 & 0.5 μM, respectively; THP-1), as well as suppresses TLR3 ligand poly(I:C)-induced IRF3 Ser396 phosphorylation (IC50 = 1 μM; Ramos) and IFNα release (IC50 = 0.79 μM; human PBMCs), a IFN positive feedback response steming from IFNβ.
Potent and highly selective tank-binding kinase-1 (TBK1) inhibitor.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000532073
0000532073
0000447115
0000447115
0000441902

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Douglas W Thomson et al.
ACS medicinal chemistry letters, 10(5), 780-785 (2019-05-18)
The serine/threonine protein kinase TBK1 (Tank-binding Kinase-1) is a noncanonical member of the IkB kinase (IKK) family. This kinase regulates signaling pathways in innate immunity, oncogenesis, energy homeostasis, autophagy, and neuroinflammation. Herein, we report the discovery and characterization of a

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