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Merck
CN

SML2724

CC2-49

≥98% (HPLC)

Synonym(s):

EN6 inactive control, EN6 negative control, N-(3-Acetamido-4-fluorophenyl)-1-(2-fluorophenyl)-1H-pyrazole-4-carboxamide, N-[3-(Acetylamino)-4-fluorophenyl]-1-(2-fluorophenyl)-1H-pyrazole-4-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C18H14F2N4O2
CAS Number:
2305350-97-2
Molecular Weight:
356.33
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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SMILES string

Fc1c(cccc1)[n]2ncc(c2)C(=O)Nc3cc(c(cc3)F)NC(=O)C

InChI key

NXUJHBGKNXUNKK-UHFFFAOYSA-N

InChI

1S/C18H14F2N4O2/c1-11(25)22-16-8-13(6-7-14(16)19)23-18(26)12-9-21-24(10-12)17-5-3-2-4-15(17)20/h2-10H,1H3,(H,22,25)(H,23,26)

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cysteine non-reactive analog of and the recommended negative (inactive) control for EN6.
CC2-49 is a cysteine non-reactive EN6 analog that lacks lysosomal vacuolar H(+)-ATPase (v-ATPase)-modifying activity, cellular mTORC1 inhibitory potency, nor autophagy-inducing efficacy. CC2-49 is the recommended negative (inactive) control for EN6.

Storage Class

11 - Combustible Solids

wgk

WGK 3

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000096692
0000096693
0000091819

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Clive Yik-Sham Chung et al.
Nature chemical biology, 15(8), 776-785 (2019-07-10)
Autophagy is a lysosomal degradation pathway that eliminates aggregated proteins and damaged organelles to maintain cellular homeostasis. A major route for activating autophagy involves inhibition of the mTORC1 kinase, but current mTORC1-targeting compounds do not allow complete and selective mTORC1

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