SML2724
CC2-49
≥98% (HPLC)
别名:
EN6 inactive control, EN6 negative control, N-(3-Acetamido-4-fluorophenyl)-1-(2-fluorophenyl)-1H-pyrazole-4-carboxamide, N-[3-(Acetylamino)-4-fluorophenyl]-1-(2-fluorophenyl)-1H-pyrazole-4-carboxamide
SMILES string
Fc1c(cccc1)[n]2ncc(c2)C(=O)Nc3cc(c(cc3)F)NC(=O)C
InChI key
NXUJHBGKNXUNKK-UHFFFAOYSA-N
InChI
1S/C18H14F2N4O2/c1-11(25)22-16-8-13(6-7-14(16)19)23-18(26)12-9-21-24(10-12)17-5-3-2-4-15(17)20/h2-10H,1H3,(H,22,25)(H,23,26)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cysteine non-reactive analog of and the recommended negative (inactive) control for EN6.
CC2-49 is a cysteine non-reactive EN6 analog that lacks lysosomal vacuolar H(+)-ATPase (v-ATPase)-modifying activity, cellular mTORC1 inhibitory potency, nor autophagy-inducing efficacy. CC2-49 is the recommended negative (inactive) control for EN6.
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
新产品
此项目有
Clive Yik-Sham Chung et al.
Nature chemical biology, 15(8), 776-785 (2019-07-10)
Autophagy is a lysosomal degradation pathway that eliminates aggregated proteins and damaged organelles to maintain cellular homeostasis. A major route for activating autophagy involves inhibition of the mTORC1 kinase, but current mTORC1-targeting compounds do not allow complete and selective mTORC1
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