SML2760
SGC6870
≥98% (HPLC)
Synonym(s):
(R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-4,5-dihydro-1H-benzo[e][1,4]diazepin-2(3H)-one
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About This Item
Empirical Formula (Hill Notation):
C23H21BrN2O2S
Molecular Weight:
469.39
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +260 to +300°, c = 0.5 in methanol
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Biochem/physiol Actions
Potent and selective protein arginine methyltransferase PRMT6 inhibitor.
SGC6870 is a potent and selective protein arginine methyltransferase PRMT6 inhibitor (IC50 = 77 nM by cell-free assays; IC50 = 0.8 μM against asymmetric H3R2 dimethylation of overexpressed PRMT6 in HEK293T cells) over all other PRMTs and 23 methyltransferases. The (S)-enantiomer SGC6870N is inactive toward PRMT6 and serves as an excellent control compound.
Storage Class
11 - Combustible Solids
WGK
WGK 3
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