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SML2762

RG1534

≥98% (HPLC)

Synonym(s):

2-Amino-N-((4-((5-chloropyrimidin-2-yl)oxy)-3-methylphenyl)carbamoyl)benzamide, 2-Amino-N-[[[4-[(5-chloro-2-pyrimidinyl)oxy]-3-methylphenyl]amino]carbonyl]benzamide;

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About This Item

Empirical Formula (Hill Notation):
C19H16ClN5O3
CAS Number:
150096-77-8
Molecular Weight:
397.82
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

NC1=CC=CC=C1C(NC(NC2=CC(C)=C(C=C2)OC3=NC=C(C=N3)Cl)=O)=O

InChI

1S/C19H16ClN5O3/c1-11-8-13(6-7-16(11)28-19-22-9-12(20)10-23-19)24-18(27)25-17(26)14-4-2-3-5-15(14)21/h2-10H,21H2,1H3,(H2,24,25,26,27)

InChI key

NLVSCQFSPVSAOF-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

inhibitor of hTERT promoter activity that selectively targets G-hairpin stem loop of the human telomerase reverse transcriptase gene (hTERT)
RG1534 is an inhibitor of hTERT promoter activity that selectively targets G-hairpin stem loop of the human telomerase reverse transcriptase gene (hTERT) that downregulates hTERT expression. RG1534 induces mitochondrial defects, oxidative stress, DNA damage and apoptosis in cancer cell while sparing normal cells

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000104438
0000104439
0000097626

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Jin H Song et al.
Cell chemical biology, 26(8), 1110-1121 (2019-06-04)
Increased telomerase activity is associated with malignancy and poor prognosis in human cancer, but the development of targeted agents has not yet provided clinical benefit. Here we report that, instead of targeting the telomerase enzyme directly, small molecules that bind

Global Trade Item Number

SKUGTIN
SML2762-5MG04061841401995
SML2762-25MG04061841401988

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