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Merck
CN

SML2764

Pitofenone hydrochloride

≥98% (HPLC)

Synonym(s):

2-[4-[2-(1-Piperidinyl)ethoxy]benzoyl]-benzoic acid methyl ester hydrochloride, Algifen Neo

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About This Item

Empirical Formula (Hill Notation):
C22H25NO4 · HCl
CAS Number:
1248-42-6
Molecular Weight:
403.90
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD01661944

Key Documents

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SMILES string

[Cl-].N3(CCCCC3)CCOc1ccc(cc1)C(=O)c2c(cccc2)C(=O)OC.[H+]

InChI

1S/C22H25NO4.ClH/c1-26-22(25)20-8-4-3-7-19(20)21(24)17-9-11-18(12-10-17)27-16-15-23-13-5-2-6-14-23;/h3-4,7-12H,2,5-6,13-16H2,1H3;1H

InChI key

ZRFIFDFEDPJBII-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H2O: 2 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Pitofenone is a potent muscarinic receptor antagonist. Pitofenone in combination with diclofenac exhibits potent antispasmodic effect in cholinergic spasm.
potent muscarinic receptor antagonist

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000096696
0000096697
0000089145

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K V Marthak et al.
Current medical research and opinion, 12(6), 366-373 (1991-01-01)
A single-blind, randomized clinical trial was carried out to compare the analgesic effectiveness in patients with renal colic of single intramuscular doses of diclofenac sodium (75 mg) versus a dipyrone (1 g)/spasmolytics combination, and diclofenac sodium (75 mg) versus pethidine
J Sanahuja et al.
DICP : the annals of pharmacotherapy, 24(4), 361-364 (1990-04-01)
A comparative, randomized, double-blind study of diclofenac sodium 75 mg im versus Baralgin (a combination drug composed of dipyrone and two spasmolytics) 5 mL iv was performed on 57 patients with renal colic. Both groups were comparable as to age
Shrinivas K Kulkarni et al.
Indian journal of experimental biology, 42(6), 567-569 (2004-07-21)
Biliary, ureteric and intestinal colic are extremely common clinical conditions associated with smooth muscle spasm. In the present study, antispasmodic activity was carried out against acetylcholine (10-640 ng/ml)-induced contractions on guinea pig ileum. Acetylcholine (10-640 ng/ml) induced concentration-dependent contraction of

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